(PDF) Exploring Activity-Induced Lactate Pharmacokinetics: Implications for Minimally-Invasive Monitoring

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Abstract

The monitoring of lactate levels allows for assessing athletes' endurance, holding a significant interest in the adaptation of personalized training programs. Blood lactate seems to be a robust biomarker of exercise-induced muscle fatigue. However, the clinical value of invasive measurements with commercially available blood lactate meters remains severely limited by their non-continuity. The advent of minimally invasive wearable biosensors may well overcome this limitation. The following literature review investigates lactate pharmacokinetics in the ISF during physical effort. It aims to characterize the relevance of dermal ISF as a medium for activity-induced lactate monitoring. Understanding the pharmacokinetics of lactate behavior in the body, its distribution in different compartments, and the potential variations during exercise is crucial for designing clinically relevant biosensors. This synthesis of current literature aims to guide biosensor developers in creating accurate, reliable, and minimally invasive solutions for lactate monitoring in sports science and health monitoring by extension.

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